Preclinical and clinical orthotopic transplantation of decellularized/engineered tracheal scaffolds: A systematic literature review

Preclinical and clinical orthotopic transplantation of decellularized/engineered tracheal scaffolds: A systematic literature review

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Severe tracheal injuries that cannot be managed by mobilization and end-to-end anastomosis represent an flexcon reverse osmosis water storage tank unmet clinical need and an urgent challenge to face in surgical practice; within this scenario, decellularized scaffolds (eventually bioengineered) are currently a tempting option among tissue engineered substitutes.The success of a decellularized trachea is expression of a balanced approach in cells removal while preserving the extracellular matrix (ECM) architecture/mechanical properties.Revising the literature, many Authors report about different amrutharishtam price methods for acellular tracheal ECMs development; however, only few of them verified the devices effectiveness by an orthotopic implant in animal models of disease.To support translational medicine in this field, here we provide a systematic review on studies recurring to decellularized/bioengineered tracheas implantation.After describing the specific methodological aspects, orthotopic implant results are verified.

Furtherly, the only three clinical cases of compassionate use of tissue engineered tracheas are reported with a focus on outcomes.